Welcome to The Spencer Lab
The Spencer Lab is in the Section of Stem Cell Biology in the Division of Oncology in the Department of Medine at Washington University School of Medicine in St. Louis.
Research in the Spencer lab is a combination of experimental and
computational science that is focused on the common theme of the
genetics, genomics, and epigenetics of acute
myeloid leukemia. We have specific expertise in DNA methylation, 3D genome architecture, and
HOX gene expression and regulation in AML, although we are broadly interested in
epigenetics and gene regulation in cancer. We also have extensive
experience using genomic technologies to make observations in
primary human samples to understand fundamental mechanisms of
cancer genomics.
We use a range of experimental systems and techniques in our lab, including:
- Whole-exome sequencing, whole-genome sequencing, error-corrected amplicon sequencing
- Long read sequencing using Oxford Nanopore and PacBio Hifi platforms
- ChIP-seq, RNA-seq, ATAC-seq, CUT&Run, CUT&Tag
- in situ HiC, capture-C, HiChIP, PLAC-seq
- Whole-genome bisulfite sequencing
- CRISPR/Cas9 genome editing, CRISPRi epigenetic editing
- CRE-seq massively parallel reporter assays
- Single cell technologies
- Human cell lines, human pluripotent stem cells, including NIH-approved embryonic stem cells and induced pluripotent stem (iPS) cells.
- Primary human AML samples
- Mouse models
Visit the links above to learn about our research, check out our recent news and publications, meet our lab, learn about David’s clinical role at Wash U or read David’s bio.
We currently have open positions for PhD students and Postdocs to join the team (more info) !